Carbapenemase

Sharaxaad Gaaban:

Qalabkan waxaa loo isticmaalaa in lagu ogaado tayada NDM, KPC, OXA-48, IMP iyo VIM carbapenemases ee laga soo saaro muunado bakteeriyada ah oo la helay ka dib dhaqanka in vitro.

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HWTS-OT085E/F/G/H -Qalabka lagu ogaanayo Carbapenemase

Epidemiology

Antibiyootikada Carbapenem waa antibiyootiko β-lactam oo aan caadi ahayn oo leh spectrum bakteeriyada ugu ballaadhan iyo waxqabadka bakteeriyada ugu xooggan^[1]. Sababtoo ah xasiloonida β-lactamase iyo sunta hoose, waxay noqotay mid ka mid ah daawooyinka bakteeriyada ugu muhiimsan ee daaweynta caabuqyada bakteeriyada daran. Carbapenems aad bay u deggan yihiin β-lactamases (ESBLs), koromosoomyada iyo cephalosporinases plasmid-dhexdhexaadin ah (AmpC enzymes)^[2].

Qiyaasta Farsamada

Gobolka la beegsanayo	NDM, KPC, OXA-48, IMP iyo VIM carbapenemases
Heerkulka kaydinta	4℃-30℃
Tusaalaha nooca	Tijaabooyin bakteeriyada la helay ka dib dhaqanka
Nolosha shelf	24 bilood
Qalabka caawimada	Looma baahna
Alaabta Dheeraadka ah	Looma baahna
Waqtiga ogaanshaha	Tijaabooyin bakteeriyada la helay ka dib dhaqanka
LoD	Nooca NDM:0.15ng/ml Nooca KPC: 0.4ng/ml nooca OXA-48:0.1ng/ml Nooca IMP:0.2ng/ml Nooca VIM:0.3ng/ml
Saamaynta jillaab	NDM, KPC, OXA-48 nooca carbapenemase, wax saameyn ah oo jillaab ah lagama helin inta u dhexeysa 100ng / mL; IMP, nooca VIM ee carbapenemase, wax saameyn ah oo jillaab ah lagama helin inta u dhexeysa 1μg/mL.