Clostridium Difficile Glutamate Dehydrogenase (GDH) iyo Toxin A/B

Clostridium difficile (CD) waa bacillus gram-positive ah oo qasab ah, kaas oo ah noole caadi ah oo ku jira jirka aadanaha. Dhirta kale waa laga hor istaagi doonaa inay tarmaan sababtoo ah antibiyootikada loo isticmaalo qiyaaso badan, CD-guna wuxuu ku tarmaa jirka aadanaha tiro badan. CD-gu wuxuu u qaybsan yahay noocyo soo saara sunta iyo kuwa aan soo saara sunta. Dhammaan noocyada CD-ga waxay soo saaraan glutamate dehydrogenase (GDH) marka ay tarmaan, noocyada sunta oo keliya ayaa ah kuwa keena cudur. Noocyada soo saara sunta waxay soo saari karaan laba sun, A iyo B. Sunta A waa enterotoxin, kaas oo sababi kara barar ku dhaca derbiga xiidmaha, soo gelitaanka unugyada, kordhinta gudbinta derbiga xiidmaha, dhiigbax iyo necrosis. Sunta B waa cytotoxin, kaas oo waxyeeleeya cytoskeleton, sababa pyknosis unug iyo necrosis, wuxuuna si toos ah u waxyeeleeyaa unugyada parietal ee xiidmaha, taasoo keenta shuban iyo colitis pseudomembranous.