Clostridium Difficile Glutamate Dehydrogenase (GDH) iyo Sun A/B

Clostridium difficile (CD) waa bakteeriyada anaerobic gram-positive bacillus, taas oo ah flora caadiga ah ee jidhka bini'aadamka. Dhirta kale waa laga hor istaagi doonaa inay tarmaan sababtoo ah antibiyootiga loo isticmaalo qiyaaso badan, CD-gu wuxuu ku soo saaraa jidhka bini'aadamka tiro badan. CD-gu wuxuu u qaybsan yahay noocyada sunta soo saarta iyo kuwa aan sunta soo saarin. Dhammaan noocyada CD-ga waxay soo saaraan glutamate dehydrogenase (GDH) marka ay tarmaan, iyo kaliya noocyada sunta ah ayaa ah cudur-sidaha. Noocyada sunta soo saara waxay soo saari karaan laba sun ah, A iyo B. Sunta A waa enterotoxin, taas oo keeni karta caabuqa derbiga mindhicirka, unugyada unugyada, korodhka qulqulka derbiga mindhicirka, dhiig-baxa iyo necrosis. Sunta B waa cytotoxin, taas oo dhaawaceysa cytoskeleton, waxay sababtaa pyknosis unug iyo necrosis, waxayna si toos ah u dhaawacdaa unugyada parietal xiidmaha, taas oo keenta shuban iyo colitis pseudomembranous.