Clostridium Difficile Glutamate Dehydrogenase(GDH) iyo Sun A/B

Clostridium difficile (CD) waa bakteeriyada anaerobic gram-positive bacillus, taas oo ah flora caadiga ah ee jidhka bini'aadamka.Dhirta kale waa laga joojin doonaa inay tarmaan sababtoo ah antibiyootiga loo isticmaalo qiyaaso badan, CD-gu wuxuu ku soo saaraa jidhka bini'aadamka tiro badan.CD-gu wuxuu u qaybsan yahay noocyada sunta soo saarta iyo kuwa aan sunta soo saarin.Dhammaan noocyada CD-ga waxay soo saaraan glutamate dehydrogenase (GDH) marka ay tarmaan, iyo kaliya noocyada sunta ah ayaa ah cudur-sidaha.Noocyada sunta soo saara waxay soo saari karaan laba sun ah, A iyo B. Sunta A waa enterotoxin, taas oo keeni karta caabuq ku dhaca derbiga mindhicirka, unugyada unugyada, kororka qulqulka derbiga mindhicirka, dhiig-baxa iyo necrosis.Sunta B waa cytotoxin, taas oo dhaawaceysa cytoskeleton, sababa pyknosis unug iyo necrosis, waxayna si toos ah u dhaawacdaa unugyada parietal xiidmaha, taasoo keenta shuban iyo colitis pseudomembranous.