Laga soo bilaabo Maajo 2022, kiisaska mpox ayaa laga soo sheegay waddamo badan oo aan cidhiidhi ahayn oo adduunka ah iyada oo la faafiyo bulshada.
26kii Ogosto, Hay'adda Caafimaadka Adduunka (WHO) waxay soo saartay heer caalami ahU Diyaargarowga Istaraatiijiga ah iyo Qorshaha Jawaabtasi loo joojiyo faafitaanka isu-gudbinta bini'aadamka ee mpox iyada oo loo marayo dadaallada caalamiga ah ee la isku dubariday, heer gobol iyo heer qaran. Tani waxay daba socotaa ku dhawaaqistii xaalad degdeg ah oo caafimaadka dadweynaha oo walaac caalami ah uu ku dhawaaqay Agaasimaha Guud ee WHO 14kii Agoosto.
Waa in la ogaadaa in cudurka dillaacay mpox uu wakhtigan ka duwan yahay kii 2022, kaas oo inta badan ku faafay ragga u galmooda ragga, iyo heerka dhimashada dadka cudurkani uu ka yaraa 1%.
Cadaadiskii ugu dambeeyay ee baahsanaa "Clade Ib", kaas oo ah kala duwanaanshiyaha Clade I, ayaa leh heerka dhimashada sare. Kala duwanaanshiyahan cusub ayaa bilaabay inuu ku fido DRC Sebtembar la soo dhaafay, markii hore wuxuu ku dhex faafay dadka ka shaqeeya galmada, wuxuuna hadda ku faafay kooxaha kale, iyadoo carruurtu ay si gaar ah u nugul yihiin.
Africa CDC ayaa warbixin ay soo saartay bishii hore ku sheegtay in cudurka mpox laga helay 10 wadan oo Afrikaan ah sanadkan, oo ay ku jirto DRC, oo sheegtay 96.3% dhammaan kiisaska Afrika sanadkan iyo 97% dhimashada. Waxaa xusid mudan in ku dhawaad 70% kiisaska DRC ay yihiin caruur da'doodu ka yar tahay 15 sano jir, kooxdan ayaa 85% ka ah dhimashada dalka.
Mpox waa zoonosis uu keeno fayraska mpox oo leh muddada soo-baxa 5 ilaa 21 maalmood, inta badan 6 ilaa 13 maalmood. Qofka cudurka qaba ayaa yeelan doona calaamado ay ka mid yihiin qandho, madax-xanuun iyo qanjidhada oo barara, ka dibna ay ku xigto finan wajiga iyo qaybaha kale ee jidhka, kuwaas oo si tartiib tartiib ah u koraan finan waxayna soconayaan ilaa toddobaad ka hor inta aan la xoqin. Kiisku waa la kala qaadaa laga bilaabo bilawga calaamadaha ilaa ay qoloftu si dabiici ah uga dhacdo.
Imtixaanka Macro & Micro-Test wuxuu bixiyaa tijaabooyin degdeg ah, xirmooyinka molecular iyo xalalka isku xigxiga ee ogaanshaha fayraska mpox, caawinta ogaanshaha fayraska mpox ee waqtiga-waqtiga, kormeerka asalkiisa, abtirsiimada, gudbinta iyo kala duwanaanshaha genomic:
Fayraska Busbuska AntigenQalabka Daahfurka (Immunochromatography)
Muunad fudud (dareeraha finan cunaha) iyo natiijo degdeg ah 10-15 daqiiqo gudahood;
Dareenka sare ee LoD ee 20pg/ml oo daboolaya Clade I & II;
Gaar ahaan heer sare ah oo aan lahayn falcelinta fayraska furuqa, fayraska varicella zoster, fayraska rubella, fayraska herpes simplex, iwm.
OPA ee 96.4% marka la barbar dhigo NAATs;
Codsi ballaaran sida kastamka, CDC-yada, farmashiyeyaasha, rugaha caafimaadka, isbitaallada ama guriga.
Xirmada ogaanshaha fayraska Busbuska ee IgM/IgG(Immunochromatographhy)
Hawlgal sahlan oo aan qalab lahayn iyo natiijo degdeg ah 10 min gudahood;
Dareenka sare iyo gaarnimada daboolaya Clade I & II;
Aqoonsada IgM iyo IgG si loo go'aamiyo heerarka caabuqa mpox;
Codsi ballaaran sida kastamka, CDC-yada, farmashiyeyaasha, rugaha caafimaadka, isbitaallada ama guriga;
Ku habboon baaritaanka baaxadda weyn ee caabuqa mpox ee looga shakisan yahay.
Xirmada ogaanshaha Asiidhka Nucleic-ka ee Busbuska (Enzymatic Probe Isothermal Amplification)
Dareen sare oo leh LoD oo ah 200 nuqul/mL oo leh IC, oo la mid ah florescence PCR;
Hawlgal sahlan: Muunad lyophiled oo lagu daray tuubada reagent lyophilized si toos ah baahida loo qabo oo ay karti u siisay qaybo madax banaan ee Nidaamka Amp Easy;
Gaar ahaan heer sare ah oo aan lahayn falcelin iskutallaab ah oo leh fayraska furuqa, fayraska tallaalka, fayraska lo'da, fayraska mousepox, fayraska herpes simplex, fayraska varicella-zoster, iyo genome-ka aadanaha, iwm.;
Muunad fudud oo fudud (dareeraha finan yaryar / suufka oropharyngeal) iyo natiijada ugu dhakhsaha badan 5 daqiiqo gudahood;
Waxqabad caafimaad oo heersare ah oo daboolaya Clade I & II oo leh PPA 100%, NPA ee 100%, OPA ee 100% iyo Kappa Qiimaha 1.000 marka la barbar dhigo qalabka Fluorescence PCR;
Nooca Lyophilized ee u baahan kaliya gaadiidka heerkulka qolka iyo kaydinta ayaa awood u siinaya helitaanka dhammaan gobollada;
Xaalado dabacsan oo rugaha caafimaadka ah, xarunta daryeelka caafimaadka, oo ay weheliso Easy Amp ee ogaanshaha baahida;
Xirmada Baadhista Asiidhka Nucleic Acid (Fluorescence PCR)
Hiddo-sidaha laba-geesoodka ah ee lala beegsaday dareen sare leh LoD oo ah 200 koobi/mL;
Muunad dabacsanaan leh ee dareeraha finan, suufka cunaha iyo serum;
Gaar ahaan heer sare ah oo aan lahayn falcelin iskutallaab ah oo leh fayraska furuqa, fayraska tallaalka, fayraska lo'da, fayraska mousepox, fayraska herpes simplex, fayraska varicella-zoster, iyo genome-ka aadanaha, iwm.;
Hawlgal sahlan: shaybaar degdeg ah oo muunad muunad ah oo lagu sii daayo tuubada falcelinta;
Ogaanshaha degdega ah: natiijada 40 daqiiqo gudahood;
Saxnimada waxaa lagu hubiyaa xakamaynta gudaha oo ilaalinaysa dhammaan habka ogaanshaha;
Waxqabad caafimaad oo heersare ah oo daboolaya Clade I & II oo leh PPA 100%, NPA ee 99.40%, OPA ee 99.64% iyo Qiimaha Kappa ee 0.9923 marka la barbar dhigo isku xigxiga;
Nooca Lyophilized ee u baahan kaliya gaadiidka heerkulka qolka iyo kaydinta ayaa awood u siinaya helitaanka dhammaan gobollada;
La jaanqaadi kara Nidaamyada PCR Fluorescence caadiga ah;
Xaalado dabacsan oo isbitaallada, CDC-yada iyo shaybaadhka;
Fayraska Orthopox Universal Nooca/Busbuska Virus-ka Qalabka Lagu Ogaado Ashitada Nukliyeerka (Fluorescence PCR)
Daboolista buuxa: waxay tijaabisaa dhammaan 4-ta fayraska Orthopox ee ku dhici kara bini'aadamka iyo mpox baahsan (Clade I&II oo lagu daray) hal tijaabo si looga fogaado in la waayo;
Dareen sare oo leh LoD oo ah 200 koobi/ml;
Gaar ahaan heer sare ah iyada oo aan falcelin iskutallaab ah lala yeelan cudur-sidaha kale ee keena finan sida fayraska herpes simplex, fayraska varicella-zoster, iyo genome-ka aadanaha, iwm.;
Hawlgal sahlan: shaybaar degdeg ah oo muunad muunad ah oo lagu darayo halbeegga falcelinta tuubada;
Ogaanshaha degdega ah: si degdeg ah u kordhinta natiijada 40 min gudahood;
Saxnimada waxaa lagu hubiyaa xakamaynta gudaha oo ilaalinaysa dhammaan habka ogaanshaha;
La jaanqaadi kara Nidaamyada PCR Fluorescence caadiga ah;
Xaalado dabacsan oo isbitaallada, CDC-yada iyo shaybaadhka;
BusbuskaViris Tku dhufoNkleicAcidDqiyaasidKwaa (Fluorescence PCR)
Isla mar ahaantaana tilmaamaysa Clade I iyo Clade II, taas oo muhiim u ah fahamka sifooyinka faafa ee fayraska, raadinta gudbintiisa, iyo samaynta ka hortagga iyo xakamaynta la beegsaday.
Dareen sare oo leh LoD oo ah 200 koobi/mL;
Muunad dabacsanaan leh ee dareeraha finan, suufka oropharyngeal iyo serum;
Gaar ahaan heer sare ah oo aan lahayn falcelin iskutallaab ah oo u dhexeeya Clade I iyo II, cudur-sidaha kale ee keena finan sida fayraska herpes simplex, fayraska varicella-zoster, iyo genome-ka aadanaha, iwm.;
Hawlgal sahlan: shaybaar degdeg ah oo muunad muunad ah oo lagu darayo halbeegga falcelinta tuubada;
Ogaanshaha degdega ah: natiijada 40 daqiiqo gudahood;
Saxnimada waxaa lagu hubiyaa xakamaynta gudaha oo ilaalinaysa dhammaan habka ogaanshaha;
Nooca Lyophilized ee u baahan kaliya gaadiidka heerkulka qolka iyo kaydinta ayaa awood u siinaya helitaanka dhammaan gobollada;
La jaanqaadi kara Nidaamyada PCR Fluorescence caadiga ah;
Xaalado dabacsan oo isbitaallada, CDC-yada iyo shaybaadhka;
Fayraska Daanyeer Universal GenomeOgaanshahaKit (Multi-PCR NGS)
Xirmada ogaanshaha cudurka Busbuska ee dhowaan la sameeyay ee Macro & Micro-Test ee xaalado kala duwan, oo ay weheliso taxanaha ONT nanopore, waxay heli karaan MPXV isku xigxiga genome-ga oo dhan oo leh dabool aan ka yarayn 98% 8 saacadood gudahood.
Fudud in lagu shaqeeyo: tignoolajiyada hal-tallaabo ee kor u qaadida patented, dhammaan taxanaha genome ee fayraska mpox waxaa lagu heli karaa cod-weyney hal wareeg ah;
Xasaasi ah oo sax ah: wuxuu ogaadaa shaybaarada hoose ilaa 32CT, iyo 600bp amplicon nanopore isku xigxiga waxay buuxin kartaa tayada sare ee ururinta genome;
Aad u-dhakhso leh: ONT waxay dhamaystiri kartaa isu-ururinta genome 6-8 saacadood gudahood;
Waafaqid ballaadhan: oo leh ONT, Qi Carbon, SALUS Pro, lllumina, MGI iyo kuwa kale ee caadiga ah 2ndiyo 3rdjiilka isku xigxiga.
Aad xasaasi u ahVirus Daanyeer oo dhan GenomeOgaanshahaKit-Illumina/MGI(Multi-PCR NGS)
Marka la eego tirada badan ee jira 2ndTaxanayaasha jiilka adduunka oo dhan, Macro & Micro-Test ayaa sidoo kale soo saaray xirmooyin xasaasi ah oo la qabsanaya taxanaha caadiga ah si loo gaaro muunad uruurin hooseeysa oo isku xigxiga genome-ga fayraska;
Kordhinta hufan: 1448 lammaane oo 200bp amplicon ultra-cufan naqshadaynta aasaasiga ah ee hufnaanta sare ee hufnaanta iyo daboolka lebbiska;
Hawl fudud: Mpox fayraska lumina/MGI maktabadda waxa lagu heli karaa cod-weyney laba wareeg ah 4 saacadood gudahood, iyadoo laga fogaanayo tillaabooyinka dhismaha maktabadda adag iyo kharashyada reagenta;
Dareenka sare: wuxuu ogaadaa shaybaarada hoose ilaa 35CT, si wax ku ool ah isaga ilaalinaya natiijooyinka beenta ah ee ay sababto jajabnaanta jajabka ama lambarka koobiga hooseeya;
Waafaqid balaadhan oo la socota guud ahaan 2ndtaxanaha jiilka sida lllumina, Salus Pro ama MGI;Ilaa hadda, in ka badan 400 oo xaaladood oo caafimaad ayaa la dhammaystiray.
Waqtiga boostada: Agoosto-28-2024