Sannad kasta 17-ka Abriil waa maalinta kansarka adduunka.
01 Dulmarka Dhacdooyinka Kansarka Adduunka
Sanadihii ugu dambeeyay, iyadoo nolosha dadka iyo cadaadiska maskaxda ay si isdaba joog ah u kordhayaan, dhacdooyinka burooyinka ayaa sidoo kale sii kordhaya sanadba sanadka ka dambeeya.
Burooyinka halista ah (kansarrada) waxay noqdeen mid ka mid ah dhibaatooyinka caafimaad ee ugu waaweyn ee sida ba'an khatar ugu ah caafimaadka dadka Shiinaha.Marka loo eego xogtii ugu dambeysay ee tirakoobka, dhimashada burooyinka halista ah ayaa ah 23.91% dhammaan sababaha dhimashada dadka deegaanka, iyo dhacdooyinka iyo dhimashada burooyinka halista ah ayaa sii kordhayay tobankii sano ee la soo dhaafay.Laakiin kansarku macnaheedu maaha "xukun dil."Ururka Caafimaadka Adduunku wuxuu si cad u tilmaamay in ilaa iyo goor hore la ogaado, 60% -90% kansarka la daweyn karo!Saddex meelood meel ka mid ah kansarka waa laga hortegi karaa, saddex meelood meel ka mid ah kansarka waa la daweyn karaa, iyo saddex meelood meel ka mid ah kansarka ayaa la daweyn karaa si ay u dheereeyaan nolosha.
02 Waa maxay buro
Burada waxaa loola jeedaa noolaha cusub ee ay sameysteen badinta unugyada unugyada deegaanka ee hoos yimaada ficilka arrimo kala duwan oo tumorigenic ah.Daraasaduhu waxay ogaadeen in unugyada burooyinka ay ku dhacaan isbeddello dheef-shiid kiimikaad oo ka duwan unugyada caadiga ah.Isla mar ahaantaana, unugyada burooyinka waxay la qabsan karaan isbeddelada jawiga dheef-shiid kiimikaadka iyaga oo u kala beddelaya glycolysis iyo fosforyaalka oksaydhka.
03 Daaweynta Kansarka Shakhsi ahaaneed
Daaweynta kansarka shakhsi ahaaneed waxay ku salaysan tahay xogta ogaanshaha ee hiddo-wadaha bartilmaameedka cudurka iyo natiijooyinka cilmi-baaris caafimaad oo caddayn ku salaysan.Waxay bixisaa aasaaska bukaanada si ay u helaan qorshaha daaweynta saxda ah, taas oo noqotay isbeddelka horumarinta caafimaadka casriga ah.Daraasadaha caafimaadku waxay xaqiijiyeen in marka la ogaado isbeddelka hidda-wadaha ee biomarkers, hiddaha SNP-ga, hiddaha iyo heerka muujinta borotiinka ee shaybaarka bayoolojiga ee bukaannada burooyinka si loo saadaaliyo waxtarka daroogada iyo qiimeynta saadaasha, iyo hagida daaweynta shakhsi ahaaneed ee kiliinikada, waxay hagaajin kartaa waxtarka waxayna yareyn kartaa waxyeellada. falcelinta , si kor loogu qaado isticmaalka macquulka ah ee ilaha caafimaadka.
Baaritaanka molecular ee kansarka waxaa loo qaybin karaa 3 nooc oo waaweyn: ogaanshaha, dhaxalka, iyo daaweynta.Tijaabada daawayntu waxay udub dhexaad u tahay waxa loogu yeero "pathology theapeutic pathology" ama daawada shakhsi ahaaneed, iyo aad iyo aad u badan oo ka hortagga unugyada iyo ka hortagga molecule yaryar kuwaas oo bartilmaameedsan kara hiddo-wadaha gaarka ah ee burooyinka iyo dariiqyada calaamadaha ayaa lagu dabaqi karaa daaweynta burooyinka.
Daawaynta molecular bartilmaameedka ah ee burooyinka ayaa bartilmaameedsada molecules-ka unugyada burooyinka waxayna faragelisaa habka unugyada kansarka.Saameynteedu waxay inta badan ku dhacdaa unugyada burooyinka, laakiin waxay saameyn yar ku leedahay unugyada caadiga ah.Receptors factor koritaanka burada, molecules transduction signal, borotiinada wareegga unugyada, apoptosis regulators, proteolytic enzymes, factor koritaanka endothelial vascular, iwm oo dhan waxaa loo isticmaali karaa sida bartilmaameedyada molecular ee daaweynta burada.Diseembar 28, 2020, "Tallaabooyinka Maamulka ee Codsiga Kiliinikada ee Dawooyinka Antineoplastic (Trial)" oo ay soo saartay Komishanka Caafimaadka iyo Caafimaadka Qaranka ayaa si cad u tilmaamay in: Daawooyinka leh bartilmaameedyada hidde-sidaha cad, mabda'a isticmaalkooda waa in la raaco kadib baaritaanka hidda-socodka ee bartilmaameedka ah.
04 Baarista hidde-sidaha ee buro
Waxaa jira noocyo badan oo isbeddellada hidde-sidaha ee burooyinka, iyo noocyada kala duwan ee isbeddellada hidde-sidaha waxay isticmaalaan dawooyin kala duwan oo la beegsaday.Kaliya marka la caddeeyo nooca beddelka hidda-wadaha oo si sax ah loo doorto daawaynta mukhaadaraadka ee la beegsaday ayaa bukaannadu ka faa'iidaysan karaan.Hababka ogaanshaha molecular ayaa loo isticmaalay si loo ogaado kala duwanaanshaha hidda-socodka ee la xidhiidha daawooyinka sida caadiga ah loo bartilmaameedsado ee burooyinka.Marka la falanqeeyo saamaynta kala duwanaanshaha hidde-sidaha ee waxtarka daroogada, waxaan ka caawin karnaa dhakhaatiirta inay horumariyaan qorshaha daaweynta shakhsi ahaaneed ee ugu habboon.
05 Xalka
Macro & Micro-Test waxay soo saartay xirmooyin taxane ah oo lagu ogaanayo hidda-wadaha burada, taasoo bixisa xal guud oo daawaynta la beegsanayo.
Qalabka Ogaanshaha Isbeddellada EGFR Aadanaha ee Gene 29 (Pluorescence PCR)
Qalabkan waxa loo isticmaalaa in vitro si tayo leh loo ogaado isu-beddellada caadiga ah ee exons 18-21 ee hiddo-wadaha EGFR ee muunado laga soo qaaday bukaannada kansarka sambabada ee unugga yar yar.
1. Nidaamku wuxuu soo bandhigayaa xakamaynta tayada tixraaca gudaha, kaas oo si buuxda ula socon kara habka tijaabada iyo hubinta tayada tijaabada.
2. Dareen sare: Ogaanshaha xalka falcelinta aashitada nucleic waxay si adag u ogaan kartaa heerka isbeddelka 1% ee ka hooseeya asalka 3ng/μL nooca duurjoogta ah.
3. Gaar ahaan heer sare ah: Wax falcelin ah ma leh DNA-da genomic aadanaha nooca duurjoogta ah iyo noocyada kale ee mutant.
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KRAS 8 Qalabka Ogaanshaha Isbeddellada (Fluorescence PCR)
Qalabkan waxaa loogu talagalay in lagu ogaado tayada tayada ee vitro ee 8 isbeddellada ee codons 12 iyo 13 ee hiddo-wadaha K-ras ee laga soo saaray DNA-da qaybaha baaraffin-ku-xidhan ee bini'aadamka.
1. Nidaamku wuxuu soo bandhigayaa xakamaynta tayada tixraaca gudaha, kaas oo si buuxda ula socon kara habka tijaabada iyo hubinta tayada tijaabada.
2. Dareen sare: Ogaanshaha xalka falcelinta aashitada nucleic waxay si adag u ogaan kartaa heerka isbeddelka 1% ee ka hooseeya asalka 3ng/μL nooca duurjoogta ah.
3. Gaar ahaan heer sare ah: Wax falcelin ah ma leh DNA-da genomic aadanaha nooca duurjoogta ah iyo noocyada kale ee mutant.
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Bani'aadamka EML4-ALK Qalabka Ogaanshaha Isku-beddelka Hiddaha (Fluorescence PCR)
Qalabkan waxa loo isticmaalaa in si tayo leh lagu ogaado 12 nooc oo beddelaad ah oo EML4-ALK ah hiddo-wadaha isku dhafka ah ee muunado ee bukaannada kansarka sambabada ee unugyada aan yarayn ee gudaha vitro.
1. Nidaamku wuxuu soo bandhigayaa xakamaynta tayada tixraaca gudaha, kaas oo si buuxda ula socon kara habka tijaabada iyo hubinta tayada tijaabada.
2. Dareenka sare: Qalabkani waxa uu ogaan karaa isku-bedelka fiyuuska oo ka hooseeya 20 nuqul.
3. Gaar ahaan heer sare ah: Wax falcelin ah ma leh DNA-da genomic aadanaha nooca duurjoogta ah iyo noocyada kale ee mutant.
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Qalabka Ogaanshaha Isku-beddelka Hiddaha ee Bani'aadamka ROS1 (Fluorescence PCR)
Xirmadan waxa loo isticmaalaa in lagu ogaado in vitro lagu ogaanayo tayada 14ka nooc ee isku-bedelka hidda-wadaha ROS1 ee shaybaarada kansarka sambabada unugyada aan-yarayn ee bini'aadamka.
1. Nidaamku wuxuu soo bandhigayaa xakamaynta tayada tixraaca gudaha, kaas oo si buuxda ula socon kara habka tijaabada iyo hubinta tayada tijaabada.
2. Dareenka sare: Qalabkani waxa uu ogaan karaa isku-bedelka fiyuuska oo ka hooseeya 20 nuqul.
3. Gaar ahaan heer sare ah: Wax falcelin ah ma leh DNA-da genomic aadanaha nooca duurjoogta ah iyo noocyada kale ee mutant.
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Qalabka ogaanshaha isbeddelka ee BRAF Gene V600E (Fluorescence PCR)
Xirmadan tijaabada ah waxaa loo isticmaalaa in si tayo leh lagu ogaado isu-beddelka hidda-wadaha BRAF V600E ee muunadaha nudaha paraffin-ku-xidhan ee melanoma ee bini'aadamka, kansarka mindhicirka, kansarka tayroodhka iyo kansarka sanbabada ee vitro.
1. Nidaamku wuxuu soo bandhigayaa xakamaynta tayada tixraaca gudaha, kaas oo si buuxda ula socon kara habka tijaabada iyo hubinta tayada tijaabada.
2. Dareen sare: Ogaanshaha xalka falcelinta aashitada nucleic waxay si adag u ogaan kartaa heerka isbeddelka 1% ee ka hooseeya asalka 3ng/μL nooca duurjoogta ah.
3. Gaar ahaan heer sare ah: Wax falcelin ah ma leh DNA-da genomic aadanaha nooca duurjoogta ah iyo noocyada kale ee mutant.
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| Lambarka buugaagta | Magaca Alaabta | Tilmaamid |
| HWTS-TM012A/B | Qalabka Ogaanshaha Isbeddellada EGFR ee Aadanaha (Pluorescence PCR) | 16 shaybaar / qalab, 32 tijaabo/xirmo |
| HWTS-TM014A/B | KRAS 8 Qalabka Daahfurka Isbeddellada (Fluorescence PCR) | 24 tijaabo/xirmo,48 tijaabo/xirmo |
| HWTS-TM006A/B | Bani'aadamka EML4-ALK Qalabka Ogaanshaha Isku-beddelka Hiddaha (Fluorescence PCR) | 20 tijaabo/xirmo,50 tijaabo/xirmo |
| HWTS-TM009A/B | Qalabka Ogaanshaha Isku-beddelka Hiddaha ee Bani'aadamka ROS1 (Fluorescence PCR) | 20 tijaabo/xirmo,50 tijaabo/xirmo |
| HWTS-TM007A/B | Qalabka ogaanshaha isbeddelka ee BRAF Gene V600E (Fluorescence PCR) | 24 tijaabo/xirmo,48 tijaabo/xirmo |
| HWTS-GE010A | Qalabka ogaanshaha isku-dhafan ee Aadanaha ee BCR-ABL (Fluorescence PCR) | 24 tijaabo/xirmo |
Waqtiga boostada: Abriil-17-2023