Aadanaha CYP2C9 iyo VKORC1 Gene Polymorphism

Sharaxaad Gaaban:

Qalabkani waxa uu quseeyaa in vitro lagu ogaado tayada tayada leh ee CYP2C9*3 (rs1057910, 1075A>C) iyo VKORC1 (rs9923231, -1639G>A) ee DNA-da genomic ee shaybaarada dhiiga oo dhan.


Faahfaahinta Alaabta

Tags Product

Magaca alaabta

HWTS-GE014A-Baadmiga CYP2C9 iyo VKORC1 Qalabka Ogaanshaha ee Polymorphism (Fluorescence PCR)

Shahaado

CE/TFDA

Epidemiology

Warfarin waa daawada xinjirowga lidka ku ah afka ee sida caadiga ah loo isticmaalo waxqabadka kiliinikada hadda, kaas oo inta badan loogu talagalay ka hortagga iyo daaweynta cudurrada thromboembolic.Si kastaba ha ahaatee, warfarin waxay leedahay daaqad daawaynta xaddidan oo aad ugu kala duwan jinsiyadaha iyo shakhsiyaadka kala duwan.Tirakoobyadu waxay muujiyeen in farqiga qiyaasta deggan ee shakhsiyaadka kala duwan ay ka badan karto 20 jeer.Dhiigbaxa falcelinta xun wuxuu ku dhacaa 15.2% bukaanada qaata warfarin sanad walba, kuwaas oo 3.5% ay yeeshaan dhiigbax dilaa ah.Daraasadaha farmashiyaha ayaa muujiyay in polymorphism-ka hidda-socodka ee bartilmaameedka enzyme VKORC1 iyo dheef-shiid kiimikaadka CYP2C9 ee warfarin ay tahay arrin muhiim ah oo saameynaysa farqiga u dhexeeya qiyaasta warfarin.Warfarin waa ka hortag gaar ah oo fiitamiin K epoxide reductase (VKORC1), oo sidaas awgeed waxay joojisaa isku-dhafka xinjirowga ee ku lug leh fitamiin K wuxuuna bixiyaa xinjirowga lidka ku ah.Tiro badan oo daraasado ah ayaa muujiyay in hidda-wadaha polymorphism-ka ee dhiirrigeliyaha VKORC1 ay tahay qodobka ugu muhiimsan ee saameeya jinsiyadda iyo kala duwanaanshaha shakhsi ahaaneed ee qiyaasta loo baahan yahay ee warfarin.Warfarin waxaa metabolized by CYP2C9, iyo mutants si aad u gaabis ah dheefshiidka warfarin.Shakhsiyaadka isticmaala warfarin waxay leeyihiin khatar sare (laba ilaa saddex jeer ka badan) dhiigbaxa marxaladda hore ee isticmaalka.

Kanaalka

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Qiyaasaha Farsamada

Kaydinta Dareeraha: ≤-18℃
Nolosha shelf 12 bilood
Nooca Tuunada Dhiig cusub oo EDTA ka-hortagga xuubka
CV ≤5.0%
LoD 1.0ng/μL
Gaar ahaan Ma jiro falcelin iskutallaab ah oo leh taxanaha kale ee aadka u joogtada ah ee genome-ka bini'aadamka (beerka bini'aadamka ee CYP2C19, hiddo-wadaha RPN2 ee aadanaha);isbeddelka CYP2C9*13 iyo VKORC1 (3730G>A)
Qalabka lagu dabaqi karo Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah

Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah ee degdegga ah

QuantStudio®5 Nidaamyada PCR-waqtiga-dhabta ah

SLAN-96P Nidaamyada PCR-waqtiga-dhabta ah

LightCycler®480 Nidaamka PCR-waqtiga-dhabta ah

LineGene 9600 Plus-Waqtiga dhabta ah ee PCR Nidaamka ogaanshaha

MA-6000-waqtiga-dhabta ah ee cabbirka kulaylka wareegga

BioRad CFX96 Nidaamka PCR-waqtiga-dhabta ah

BioRad CFX Opus 96 Nidaamka PCR-waqtiga-dhabta ah

Socodka Shaqada

Soo saarista lagu taliyay: Macro & Micro-Tijaabo Viral DNA/RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) 3006).


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