Ogaanshaha Muhiimka ah ee BCR-ABL ee Daawaynta CML

Chronic myelogenousleukemia (CML) waa cudur xinjirowga lidka ku ah ee unugyada tarma ee hematopoietic. In ka badan 95% bukaannada CML waxay ku wataan koromosoomyada Philadelphia (Ph) ee unugyadooda. Iyo hidda-wadaha isku-dhafka BCR-ABL waxaa sameeyay is-beddel u dhexeeya ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) oo ku taal cududda dheer ee koromosoomka 9 (9q34) iyo gobolka qaybta jaban (BCR) ee cududda dheer ee koromosoom 22 (22q11). Borotiinka isku dhafka ah ee lagu qeexay hidda-wadahani wuxuu leeyahay waxqabadka tyrosine kinase (TK), wuxuuna kiciyaa dariiqyada calaamadaha hoose (sida RAS, PI3K, iyo JAK / STAT) si kor loogu qaado kala qaybinta unugyada iyo in la xakameeyo apoptosis unug, taasoo ka dhigaysa unugyo si xun u faafaya, taasina waxay keenaysaa dhacdooyinka CML.

Hiddaha isku-dhafka BCR-ABL, oo ​​muhiim u ah horumarinta CML, waxay u adeegtaa sida calaamad muujinaysa ogaanshaha furaha. ee CML. Soo saaristeeda waxay caawisaa in lala socdo bukaanka's jawaabta tyrosine kinase inhibitors (TKIs) oo saadaaliya soo noqoshada leukemia, taas oo lagama maarmaan u ah maaraynta bukaanka CML ee waxtarka leh.

Human BCR-ABLQalabka Ogaanshaha Isku-beddelka Fusionlaga bilaabo Macro & Micro-Test oo si tayo leh loogu ogaado BCR-ABL ee bukaannada CML, caawiyaa ogaanshaha CML oo haga daawaynta kiliinikada ee la beegsaday si kor loogu qaado xeeladaha daweynta ee maaraynta bukaanka waxtarka leh.BCR-ABL fusion gene, kaaswaamuhiim ahhorumarinta CML,waxay u adeegtaa sidii calaamad muhiim ah oo ogaanshahaofCML. Ogaanshaha ay ku caawisola socodkabukaan'sjawaab celinta tyrosine kinase inhibitors (TKIs)iyowuxuu saadaaliyaa soo noqoshada leukemia, taasoo ahlama huraan ahto waxtar lehCMLmaaraynta bukaanka.

Qalabka Ogaanshaha Isku-beddelka Bani'aadamka ee BCR-ABL laga bilaabo Macro & Micro-Test si tayada tayada leh loogu ogaado BCR-ABL ee bukaanka CML, caawinCMLogaanshahaiyohagayaaldaawaynta kiliinikada ee la beegsanayotowanaajisoexeeladaha daweynta ee maaraynta bukaanka ee waxtarka leh.

dhamaystiranDfikradda:Isku marogaanshahawaayo3hiddo-wadaha isku-dhafka ah (P210, P190, P230)waayodaboolitaan ballaaran iyoka hortagga kiisaska seegay;

Dareen sare:Nooca dareeraha ah ayaa ogaanaya hidda-wadaha isku-dhafka ahoo leh LoD1000 koobi/ml,iyo nooca lyophilizedof 500 koobi/ml;

Aad u fiicanAsax ah: Igudahaxakamayniyo UNG enzyme si looga hortago been-abuurka&diidmo;

Hawl fudud iyo hufnaan:Hawlgalka tuubada xiran,free of alaabtahabsocodka ka dib,iyoogaanshahagudaha60 daqiiqowaayoujeedo iyo natiijooyin la isku halayn karo;

Wax badanIkhtiyaarada：Noocyada dareeraha iyo lyophilized ee ikhtiyaarrada macaamiisha;

Waafaqid balaadhan:La jaanqaadi kara inta badan nidaamyada PCR ee gelitaanka shaybaadhka ballaaran.