Bani'aadamka BCR-ABL Fusion Hid is beddelka

Sharaxaad Gaaban:

Qalabkani wuxuu ku habboon yahay in lagu ogaado tayada p190, p210 iyo p230 isoforms ee hidda-wadaha fusion BCR-ABL ee muunadaha dhuuxa lafta bini'aadamka.


Faahfaahinta Alaabta

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Magaca alaabta

HWTS-GE010A-Bani'aadamka BCR-ABL Xirmada Garashada Isku-beddelka Hiddaha (Fluorescence PCR)

Epidemiology

Chronic myelogenousleukemia (CML) waa cudur xinjirowga lidka ku ah oo ku dhaca unugyada tarma ee hematopoietic.In ka badan 95% bukaannada CML waxay ku wataan koromosoomyada Philadelphia (Ph) ee unugyadooda.Cudurka ugu badan ee CML waa sida soo socota: Hidde-celinta isku-dhafka BCR-ABL waxaa lagu sameeyay beddelka u dhexeeya abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ee cududda dheer ee koromosoomka 9 (9q34) iyo gobolka kooxda jaban ( BCR) hiddo-wadaha cududda dheer ee koromosoomyada 22 (22q11);borotiinka isku dhafka ah ee lagu dhejiyay hidde-sidahani wuxuu leeyahay firfircoonida tyrosine kinase (TK), wuxuuna dhaqaajiyaa dariiqyada calaamadaha hoose (sida RAS, PI3K, iyo JAK/STAT) si kor loogu qaado kala qaybinta unugyada iyo in la xakameeyo apoptosis unug, taasoo ka dhigaysa unugyo si xun u faafaya. dhacdadii CML .BCR-ABL waa mid ka mid ah tilmaamayaasha ogaanshaha ee muhiimka ah ee CML.Isbeddelka firfircoon ee heerkiisa qoraalku waa tilmaame lagu kalsoonaan karo oo loogu talagalay go'aaminta saadaasha ee leukemia waxaana loo isticmaali karaa in lagu saadaaliyo soo noqoshada leukemia ka dib daaweynta.

Kanaalka

FAM Hiddaha isku dhafka BCR-ABL
VIC/HEX Xakamaynta Gudaha

Qiyaasaha Farsamada

Kaydinta Dareeraha: ≤-18℃ Madow
Nolosha shelf Dareeraha: 9 bilood
Nooca Tuunada Tijaabooyin dhuuxa lafta
LoD 1000 koobi/ml

Gaar ahaan

 

Ma jiro falcelin iskutallaab ah oo leh hiddo-wadaha fiyuuska kale TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, iyo PML-RARa
Qalabka lagu dabaqi karo Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah

Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah ee degdegga ah

QuantStudio® 5 Nidaamyada PCR-waqtiga-dhabta ah

SLAN-96P Nidaamyada PCR-waqtiga-dhabta ah

LightCycler®480 Nidaamka PCR-waqtiga-dhabta ah

LineGene 9600 Plus-Waqtiga dhabta ah ee PCR Nidaamka ogaanshaha

MA-6000-waqtiga-dhabta ah ee cabbirka kulaylka wareegga

BioRad CFX96 Nidaamka PCR-waqtiga-dhabta ah

BioRad CFX Opus 96 Nidaamka PCR-waqtiga-dhabta ah


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