—— Daraasad iskaashi ah oo ay sameeyeen Zhejiang CDC, Macro & Micro-Test, iyo Shiinaha CDC oo lagu daabacay Frontiers in Cellular and Infection Microbiology.
Dulmar Guud oo ku saabsan Daraasadda
Bishii Maajo 2026, Frontiers in Cellular and Infection Microbiology (JCR Q1, IF ≈ 4.6) waxay daabacday warqad ay hoggaaminayso Xarunta Gobolka Zhejiang ee Xakamaynta iyo Kahortagga Cudurrada (Zhejiang CDC), iyadoo kooxda bioinformatics ay ka socoto Beijing Macro & Micro-Test Bio-Tech Co., Ltd. iyo Machadka Qaranka ee Xakamaynta iyo Kahortagga Cudurrada La Isqaadsiiyo (China CDC) ay yihiin qorayaal wada jira. Daraasadda waxaa cinwaan looga dhigay:
"Aqoonsiga iyo falanqaynta phylogenetic ee toddobo nooc oo Brucella abortus ah oo ku yaal Zhejiang, Shiinaha."
Daraasaddani waxay matalaysaa falanqayntii ugu horreysay ee nidaamsan, oo ku salaysan hidde-sideyaasha oo dhan ee Brucella abortus (B. abortus) ee Gobolka Zhejiang, Shiinaha. Kooxdu waxay falanqaysay toddobo go'doon oo laga soo ururiyay 2015 ilaa 2025 (afar nooc oo asal ahaan aadame ah iyo saddex nooc oo asal ahaan lo' ah oo ka yimid Jinhua, Quzhou, iyo Ningbo). Natiijooyinka waxay bixiyaan caddayn hidde-side ah oo ku saabsan asalka iyo waddooyinka gudbinta ee "noocyada waqooyiga ee ugu badan" ee ku yaal gobolka faafa ee koonfurta ee aan caadiga ahayn ee bariga Shiinaha.
Asalka iyo Muhiimadda
Brucellosis waa cudur xayawaan ah oo ay keento bakteeriyada nooca Brucella. Brucella abortus waxay inta badan ku dhacdaa lo'da laakiin waxay sidoo kale ku keeni kartaa cudur dadka. Shiinaha, brucellosis waxay muujinaysaa kala duwanaansho juqraafiyeed oo muuqda: dhacdooyinka ugu badan waxay ka dhacaan gobollada waqooyi (tusaale ahaan, Inner Mongolia, Shanxi, Heilongjiang). Taas bedelkeeda, gobollada koonfureed, oo ay ku jirto Zhejiang, taariikh ahaan waxaa ku badan Brucella melitensis, iyadoo kiisas aad u yar la soo sheegay oo ah B. abortus. Kala duwanaanshahan gobolka ayaa ka dhigaya astaamaha hidde-sidaha iyo raadinta isha ee B. abortus ee Zhejiang mudnaanta koowaad ee caafimaadka dadweynaha.
Hababka iyo Natiijooyinka Muhiimka ah
Kooxda cilmi-baarista waxay qaateen istaraatiijiyad dhinacyo badan leh oo isku daraysa bayoolajiga molecular-ka iyo bayoinformatics:
1.Aqoonsiga cudurka iyo nooca aasaasiga ah
PCR-ka hidda-wadaha BCSP-31 iyo AMOS-PCR waxay xaqiijiyeen in dhammaan toddobada go'doomin ay ahaayeen B. abortus.
Nooca taxanaha Multilocus (MLST) oo ku salaysan sagaal hiddo-wade oo guryaha lagu daryeelo ayaa shaaca ka qaaday in dhammaan go'doominta ay ka tirsan yihiin nooca taxanaha ah ee ST2, taasoo muujinaysa isku-midnimada hidde-sideyaasha sare ee noocyada B. abortus ee ku wareegaya Zhejiang.
2.Astaamaha hidde-sideyaasha oo dhan
Taxanaha hidde-sideyaasha oo dhan ayaa lagu sameeyay madal Illumina NovaSeq. Falanqaynta celceliska aqoonsiga nucleotide (ANI) waxay muujisay in go'doominta Zhejiang ay la wadaagtay ilaa 99.99% isku mid ah nooca tixraaca B. abortus 544.
Falanqaynta hidde-sideyaasha pan-genome waxay muujisay dad aad loo ilaaliyo: 3,084 hiddo-sideyaal asaasi ah ayaa la aqoonsaday, oo ay weheliyaan 10 hiddo-side oo qolof leh oo keliya, mana jirin hiddo-sideyaal asaasi ah oo jilicsan ama daruuro ah oo la helay.
3.Astaamaha hidde-sideyaasha iska caabbinta jeermiska iyo jeermiska
Wadarta guud ee 68 arrimood oo la xiriira fayraska ayaa la saadaaliyay, kuwaas oo daboolaya waddooyinka caadiga ah sida biosynthesis-ka LPS, nidaamka dheecaanka T4SS, iyo nidaamka sharciyeynta laba-qaybood ee BvrR-BvrS. Waxaa xusid mudan, dhammaan go'doominta waxay ka maqnaayeen hiddo-sidayaasha adhesin bmaA iyo btaF. Falanqaynta hiddo-sidayaasha iska caabbinta waxay ogaatay oo keliya hiddo-sidayaasha mprF ee ku jira xogta CARD, iyada oo aan la aqoonsan wax kale oo go'aamiya iska caabbinta.
4. Dib-u-dhiska phylogenetic-ga iyo raadinta gudbinta
Falanqaynta hal-nukliyeetka hal-nukliyeetka ah (cgSNP) ee hidde-sideyaasha asaasiga ah waxay dhigtay go'doominta Zhejiang meel gaar ah oo ku taal geedka phylogenetic-ga adduunka. Natiijooyinka waxay muujiyeen in noocyada Zhejiang ay sameeyaan koox monophyletic ah oo ay weheliyaan noocyo ka yimid Ruushka, Mongolia, iyo dhowr gobol oo waqooyiga Shiinaha ah (Ningxia, Heilongjiang, Inner Mongolia, Hebei, Gansu, Beijing). Kooxdani waxay si dheeraad ah u kala qaybsan tahay saddex qaybood oo kala duwan (Clade 1–3), taasoo soo jeedinaysa dhacdooyin hordhac ah oo madax-bannaan oo badan.
Gunaanad iyo Saamaynta
Daraasaddani waxay bixisaa xogta hidde-side ee ugu horreysa ee saxnaanta sare leh ee B. abortus ee Gobolka Zhejiang waxayna soo saartaa gabagabo muhiim ah dhowr:
- Clear asalka hidde-sideyaasha– Noocyada B. abortus ee ku wareegaya Zhejiang waxay ka tirsan yihiin ST2, si aad ah ayaa loo ilaaliyay, waxayna matalaan nooc caadi ah oo ah brucellosis lo'da ah.
2. Eviheerka gudbinta gobolka ee isdhaafsiga ah- Falanqaynta phylogenetic-ga ma taageerto jiritaanka abtirsiin madax-bannaan oo ku nool Zhejiang. Taa beddelkeeda, xogtu waxay si xooggan u soo jeedinaysaa in noocyadani ay ka soo jeedaan waqooyiga Shiinaha waxayna la wadaagi karaan asal isbeddel oo isku mid ah noocyada ka soo jeeda Ruushka iyo Mongolia. Joogitaanka saddex qaybood oo hoose waxay tilmaamaysaa dhacdooyin hordhac ah oo kala duwan.
3. Saamaynta caafimaadka dadweynaha– Natiijooyinka waxay hoosta ka xariiqayaan qiimaha kormeerka hidde-sideyaasha ee cudurka brucellosis xitaa gobollada aan caadiga ahayn sida Zhejiang. Inkasta oo tirada kiisaska hadda jira ay yar tahay, qalabka xallinta sare leh sida cgSNP ayaa si wax ku ool ah u raadraaci kara isha faafitaanka dibadda laga keeno waxayna bixin karaan caddayn cilmiyeed si loo joojiyo silsiladaha gudbinta ee la xiriira gaadiidka xoolaha ee gobollada dhexdooda.
Shaqadani ma buuxinayso oo keliya farqiga cilmi-baarista ee Gobolka Zhejiang laakiin sidoo kale waxay bixisaa xog aasaasi ah oo cusub oo loogu talagalay la socodka cudurrada iyo qiimeynta khatarta cudurka brucellosis ee gobolka River Delta ee Yangtze.
Macluumaadka Warqadda:
Yang, Y., Shi, X., Chen, J., Wang, L., Wu, Z., Yao, W., … & Wu, B. (2026). Falanqaynta aqoonsiga iyo phylogenetic-ga ee toddobo nooc oo Brucella abortus ah oo ku yaal Zhejiang, Shiinaha. Xuduudaha ku jira Unugyada iyo Caabuqa Microbiology, 16, 1758965.
Waqtiga boostada: Juun-10-2026