Isbadalka hiddaha aadanaha ee Ros1 Fusion

Aadanaha Ros1 Fusion hidde-ku-dhejinta muuqaalka

Sharraxaadda Gaaban:

Qalabkan waxaa loo isticmaalaa in lagu ogaado vitro tayo leh oo ah 14 nooc oo ah isbadalka hidda-wadaha ee Ros1 Fusigyada ee samafalka kansarka ee sambabka ee aan yar ee bini-aadamka (shaxda 1). Natiijooyinka baaritaanka waxaa loogu talagalay tixraac caafimaad oo keliya oo looma adeegsan doono sida ugu sahlan oo loogu talagalay daaweynta shaqsiyeed ee bukaanka.

U dir emaylka

Si faahfaafo

Calaamadaha wax soo saarka

Magaca wax soo saarka

HWTS-TM009-TM009-Aadanaha ROS1 Finisiinta Qalabka Baadhitaanka Geerida (PCR)

Shahaado

Nadiifin

Ros1 waa transmembrane crusine kinase ee qoyska soo-saare ee insulinta. Ros1 Fusion hiddo-wadaha ayaa loo xaqiijiyay inuu yahay mid kale oo muhiim ah oo aan ahayn wade-gacmeed kale oo aan yar ahayn oo aan Yar ahayn. Sida wakiil ka ah hooyooyin cusub oo mos1 hidde ah hiddo-wadaha 'Ros1' EZR, SLC34A2, iyo SDC4, waxay sii wadi doontaa inay dhaqaajiso gobolka Ros1 Tyrosine Kinse. Si aan caadi ahayn u dhaqaajiyey Ros1 Kinase wuxuu ku dhaqaajin karaa wadiiqooyinka muujinta ee hoos udhaca sida Ras / mapk / Erto, iyo JAK3, iyo JAK3, iyo Metastasis ee unugyada burooyinka, iyo kansarka. Waxaa ka mid ah isbadallada Ros1 ee ka mid ah isbadallada Ros1, CD74-Ros1 akoonnada qiyaastii 42%, EZR waxay akoonnada ku dhawaad 15%, SLC34A2 akoonnada qiyaastii 12%, iyo akoonnada SDC4 qiyaastii 7%. Daraasaduhu waxay muujiyeen in goobta 'ATP-ku-xirta' ee 'Resonal' ee Ros1 Kinase iyo goobta Atp-Mind ee ALK KINUSENT MUQDISHO KU SAABSAN SANADKA SANADKA SANADKA SANADKA SIYAASADAHA CARRIOSIBIB IYO SIDII AY KU SAMEEYSAAN DHAQANKA Daaweynta Nsclc oo leh isbadal ku saabsan Ros1. Sidaa darteed, ogaanshaha isjirallada Ros1 ayaa ah goobta iyo aasaaska si loo hago isticmaalka dawooyinka craztotintib.

Kanaal

Fa farqad	Rabsoonta Buffer 1, 2, 3 iyo 4
Vic (hex)	Dib-u-soo-celinta Buffer 4

Cayayaanka farsamada

Bakhaar	≤-18 ℃
Shelf-Life	9 bilood
Nooca muunadda	paraffin-paraffin-pafaffin-paresdy ama sanballada la jarjarey
CV	<5.0%
Ct	≤38
Dhigid	Qalabkan wuxuu ku ogaan karaa islaaminta ku fidsan illaa 20 koobi.
Aaladaha lagu dabaqi karo:	Waxaa lagu dabaqay biosystemy-ga ee lagu dabaqay 7500 nidaamyada waqtiga-dhabta ah ee PCRWaxaa lagu dabaqay bio-yariyada bio-yada lagu dabaqay 7500 oo si dhakhso leh u ah nidaamyada PCR-ga Nidaamyada Slan-96p ee waqtiga-waqtiga dhabta ah ee PCR Tijaabada Tijaabada PCR-da ee waqtiga-dhabta ah Nalalka Firfircoon480 Nidaamka PCR-ka waqtiga-dhabta ah Sadarka 9600 oo lagu daray nidaamka ogaanshaha PCR-ka waqtiga-dhabta ah MA-6000 baaskiil-ku-meel-gaadhka waqtiga-ku-meel-gaarka ah Biorad Cfx96 Nidaamka waqtiga-dhabta ah ee PCR Biorad Cfx Opus 96 Nidaamka PCR-ka waqtiga-dhabta ah