Isbeddellada KRAS 8

Isbeddellada dhibcaha ee hiddo-wadaha KRAS ayaa laga helay tiro ka mid ah noocyada burooyinka bini'aadamka, qiyaastii 17% ~ 25% heerka isbeddelka ee burada, 15% ~ 30% heerka isbeddelka ee bukaannada kansarka sanbabada, 20% ~ 50% heerka isbeddelka isbeddelka ee bukaanka kansarka mindhicirka. Sababtoo ah borotiinka P21 ee lagu dhejiyay hidda-wadaha K-ras wuxuu ku yaalaa dhinaca hoose ee dariiqa calaamadaynta EGFR, ka dib isbeddelka hidda-wadaha K-ras, dariiqa calaamadaynta hoose ayaa had iyo jeer shaqeeya oo aan saameyn ku yeelan daawooyinka korka ee bartilmaameedka ah ee EGFR, taasoo keentay kororka joogtada ah ee unugyada. Isbeddellada ku jira hidda-wadaha K-ras guud ahaan waxay iska caabbiyaan EGFR tyrosine kinase inhibitors ee bukaannada kansarka sambabada iyo iska caabbinta daawooyinka ka hortagga EGFR ee bukaanka kansarka mindhicirka. Sannadkii 2008, Shabakadda Kansarka Guud ee Qaranka (NCCN) waxay soo saartay hab-dhaqan caafimaad oo loogu talagalay kansarka mindhicirka, kaas oo tilmaamay in goobaha isbeddelka ee keena K-ras in la dhaqaajiyo ay inta badan ku yaalliin codons 12 iyo 13 of exon 2, waxayna ku talisay in dhammaan bukaannada qaba kansarka mindhicirka ee metastatic ka hor inta aan la tijaabin karin daaweynta K-ras mutation. Sidaa darteed, ogaanshaha degdega ah ee saxda ah ee beddelka hidda-wadaha K-ras ayaa muhiimad weyn u leh hagidda daawaynta. Qalabkani waxa uu u isticmaalayaa DNA-da muunadda ogaanshaha si uu u bixiyo qiimayn tayo leh oo ku saabsan xaaladda isbeddelka, kaas oo ka caawin kara dhakhaatiirta baadhista kansarka mindhicirka, kansarka sanbabada iyo bukaannada kale ee buro ee ka faa'iidaysta daawooyinka la beegsaday. Natiijooyinka baaritaanka xirmada waxaa loogu talagalay tixraaca bukaan-socodka oo keliya mana aha in loo isticmaalo saldhigga keliya ee daaweynta gaarka ah ee bukaanka. Dhakhaatiirtu waa inay sameeyaan go'aanno dhammaystiran oo ku saabsan natiijooyinka baaritaanka oo ku saleysan arrimo ay ka mid yihiin xaaladda bukaanka, calaamadaha daroogada, jawaabta daaweynta iyo tilmaamayaasha kale ee baaritaanka shaybaarka.