● Qaaxada Mycobacterium
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Mycobacterium tuberculosis Nucleic Acid iyo Rifampicin (RIF) , iska caabinta (INH)
Qalabkan waxaa loo isticmaalaa in vitro lagu ogaado tayada Mycobacterium DNA ee xaakada bini'aadamka, dhaqanka adag (LJ Dhexdhexaadiyaha) iyo dhaqanka dareeraha ah (MGIT Medium), dheecaanka boronkiitada, iyo isbeddellada ku jira 507-533 amino acid codeon (81bp, rifampicin go'aaminta caabbinta gobolka ee MycopoB). Isbeddellada ku jira goobaha ugu muhiimsan ee qaaxada Mycobacterium isoniazid resistance.Waxay gargaar siisaa ogaanshaha infekshanka qaaxada Mycobacterium, waxayna ogaataa hidda-wadaha iska caabinta ugu weyn ee rifampicin iyo isoniazid, taas oo gacan ka geysaneysa fahamka caabbinta daawada ee qaaxada Mycobacterium ee uu buka buka.
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Mycobacterium Tuberculosis INH Mutation
Qalabkani wuxuu ku haboon yahay in lagu ogaado tayada goobaha ugu muhiimsan ee isku-beddelka ee shaybaarada xaakada bini'aadamka ee laga soo ururiyay bukaanada Tubercle bacillus togan ee keena qaaxada mycobacterium INH: Gobolka dhiirigeliyaha InhA -15C>T, -8T>A, -8T>C; Gobolka horumariyaha AhpC -12C>T, -6G>A; isu beddelka qaniisyada ee KatG 315 codon 315G>A, 315G>C .
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Mycobacterium Tuberculosis iska caabinta Rifampicin
Qalabkani waxa uu ku habboon yahay in lagu ogaado tayada isku-beddelka homozygous ee gobolka 507-533 amino acid codon ee hidda-wadaha rpoB ee keena iska caabbinta Mycobacterium tuberculosis rifampicin.
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Mycobacterium tuberculosis Nucleic Acid iyo Rifampicin Resistance
Qalabkani waxa uu ku haboon yahay in lagu ogaado tayada DNA-ga ee Mycobacterium tuberculosis DNA-da ee shaybaarada xaakada bini'aadamka ee vitro, iyo sidoo kale isku-bedelka homozygous ee gobolka 507-533 amino acid codon ee hidda-wadaha rpoB ee keena iska caabbinta Mycobacterium tuberculosis rifampicin.
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Mycobacterium Tuberculosis DNA
Waxay ku habboon tahay in si tayo leh loo ogaado DNA-ga Mycobacterium tuberculosis ee shaybaarada xaakada ee bini'aadamka, waxayna ku habboon tahay ogaanshaha kaaliyaha ee caabuqa qaaxada Mycobacterium.
