● Qaaxada Mycobacterium
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Mycobacterium Tuberculosis Asiidh Nucleic iyo Rifampicin (RIF), Iska caabin (INH)
Qalabkan waxaa loo isticmaalaa ogaanshaha tayada ee DNA-da qaaxada Mycobacterium ee candhuufta aadanaha, dhaqanka adag (LJ Medium) iyo dhaqanka dareeraha (MGIT Medium), dareeraha laamiga ee bronchial, iyo isbeddellada ku yimaada gobolka codon amino acid 507-533 (81bp, gobolka go'aaminta iska caabbinta rifampicin) ee hidda-wadaha rpoB ee iska caabbinta qaaxada Mycobacterium rifampicin, iyo sidoo kale isbeddellada ku dhaca goobaha ugu muhiimsan ee qaaxada Mycobacterium isoniazid. Waxay kaa caawineysaa ogaanshaha caabuqa qaaxada Mycobacterium, waxayna ogaataa hidda-wadaha iska caabbinta ugu weyn ee rifampicin iyo isoniazid, taas oo ka caawisa fahamka iska caabbinta daawada ee qaaxada Mycobacterium ee uu ku dhacay bukaanka.
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Isbeddelka Mycobacterium Tuberculosis INH
Qalabkani wuxuu ku habboon yahay ogaanshaha tayada goobaha ugu muhiimsan ee beddelka ah ee muunadaha xaakada aadanaha ee laga soo ururiyey bukaanada qaba cudurka Tubercle bacillus ee keena qaaxada mycobacterium INH: Gobolka kor u qaada InhA -15C>T, -8T>A, -8T>C; Gobolka kor u qaada AhpC -12C>T, -6G>A; isbeddelka homozygous ee KatG 315 codon 315G>A, 315G>C.
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Mycobacterium Tuberculosis Iska caabbinta Rifampicin
Qalabkani wuxuu ku habboon yahay ogaanshaha tayada ee isbeddelka homozygous ee gobolka codon amino acid 507-533 ee hidda-wadaha rpoB ee sababa iska caabbinta Mycobacterium tuberculosis rifampicin.
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Mycobacterium Tuberculosis Aashitada Nucleic iyo Rifampicin iska caabbinta
Qalabkani wuxuu ku habboon yahay ogaanshaha tayada ee DNA-da qaaxada Mycobacterium ee muunadaha candhuufta aadanaha ee ku jira vitro, iyo sidoo kale isbeddelka homozygous ee gobolka codon amino acid 507-533 ee hidda-wadaha rpoB ee sababa iska caabbinta Mycobacterium qaaxada rifampicin.
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DNA-da Mycobacterium Tuberculosis
Waxay ku habboon tahay ogaanshaha tayada ee DNA-da qaaxada Mycobacterium ee muunadaha xaakada ee aadanaha, waxayna ku habboon tahay ogaanshaha dheeraadka ah ee caabuqa qaaxada Mycobacterium.
